Both lanes of the M80, between Junctions 8 and 9, are to close tonight.
It's part of work on a "comprehensive" resurfacing of the motorway.
The northbound carriageway will shut between 7:30pm and 6am - while the southbound side will be closed from 10pm to 6am.
Diversions will be in place, adding 10 miles on to affected journeys.
Tommy Deans, BEAR Scotland’s South East Network Manager, said: “This section of the M80 northbound is nearing the end of its service life and it is essential that we replace the road surface before it deteriorates.
“This is a significantly deeper and more comprehensive resurfacing project than is typically carried out during overnight closures. We’ll be reconstructing the road to a depth of several hundred millimetres.
“Traffic modelling indicates estimated additional delays of around 12 minutes at peak times. We’re warning road users to plan ahead and expect long delays in the hope that many will alter their travel plans to avoid this disruption.
“We appreciate the delays and disruption that these works will cause, however we’ve done everything we can to minimise the impact.
“We thank road users for their patience and understanding.”
Falkirk school week reduction to be discussed
Rally over Grangemouth refinery closure
Campaign to increase flu and Covid-19 vaccinations
Rise in spiking incidents